Dan Hart

Company: Epicrispr Biotechnologies

Job title: Head of Technology Development

Seminars:

Highlighting How Designing Compact Epigenome Editors Can Facilitate Clearance for Clinical Trials 11:30 am

Focus in on the importance of designing gene editors with delivery in mind Showcase strategies required to build a compact epigenetic gene editing platform Highlight that AAVs are well-studied in clinical trials so provide a good way forward, but a condensed gene editing platform opens the opportunity to use alternative delivery methodsRead more

day: Day Two

Roundtable: Limiting the Immunogenicity & Off-Target Effects of Editing Platforms to Enhance Therapeutic Safety & Efficacy 4:30 pm

Discuss the immunogenicity risks of bacteria-derived genome editing proteins alongside the delivery capsid Comprehend design strategies for building a genome editing platform to reduce immunogenicity and off-target effects Reinstate how addressing immunogenicity is key to maintaining a platform that is safe and efficaciousRead more

day: Day Two