Utilizing Ionizable & Non-Ionizable Lipids to Optimize LNP Extra-Hepatic Delivery
Time: 2:30 pm
day: Day One PM
Details:
- Discuss the advantages of LNPs including the ability for mRNA, transient expression, lack of integration and reduced immunogenicity
- Understand how ionizable lipids are essential for the proper packaging of the LNP, endosomal escape and subsequently for the importance of developing novel ionizable and non-ionizable lipids that can improve targeting outside the liver
- Highlight how the development of novel LNP formulations found to be more potent and more efficacious, are crucial for the future of genome editing therapeutics
