Jesse Owens
Chief Scientific Advisor Komo Biosciences
Seminars
Tuesday 29th September 2026
Roundtable Discussion: Engaging Regulators to Build Confidence in Novel Genome Editing Modalities & Accelerate Clinical Development Pathways
2:15 pm
- Educating regulatory agencies on emerging modalities including prime editing, base editing, and epigenetic editing to establish shared understanding of safety and efficacy profiles
- Implementing proactive regulatory engagement strategies throughout preclinical and clinical development to address agency concerns and align on evidence requirements for novel tools
- Establishing validation frameworks for next-generation editing technologies to streamline regulatory review and build confidence in therapeutic potential
Tuesday 29th September 2026
Advancing Non-Viral Gene Editing by Leveraging Hyperactive Integrases to Efficiently Deliver Targeted Large Cargo
1:45 pm
- Leveraging evolved phage integrases for non-viral, site-specific genomic integration to enhance safety and minimize off-target effects
- Engineering a super-efficient non-viral delivery system for large DNA fragments to overcome current limitations and unlock complex gene therapies
- Delivering exceptionally large therapeutic gene payloads (up to 16kb) to address complex multi-gene disorders and reduce manufacturing costs
