Dan Hart
Seminars
Thursday 30th October 2025
Roundtable: Limiting the Immunogenicity & Off-Target Effects of Editing Platforms to Enhance Therapeutic Safety & Efficacy
1:30 pm
- Discuss the immunogenicity risks of bacteria-derived genome editing proteins alongside the delivery capsid
- Comprehend design strategies for building a genome editing platform to reduce immunogenicity and off-target effects
- Reinstate how addressing immunogenicity is key to maintaining a platform that is safe and efficacious
Friday 31st October 2025
Highlighting How Designing Compact Epigenome Editors Can Facilitate Clearance for Clinical Trials
12:00 pm
- Focus in on the importance of designing gene editors with delivery in mind
- Showcase strategies required to build a compact epigenetic gene editing platform
- Highlight that AAVs are well-studied in clinical trials so provide a good way forward, but a condensed gene editing platform opens the opportunity to use alternative delivery methods
